Human dopamine D1 receptor encoded by an intronless gene on chromosome 5

@article{Sunahara1990HumanDD,
  title={Human dopamine D1 receptor encoded by an intronless gene on chromosome 5},
  author={Roger K. Sunahara and Hyman B. Niznik and David M. Weiner and Thomas M. Stormann and Mark R. Brann and James L. Kennedy and Joel Gelernter and Richard F. Rozmahel and Yili Yang and Yedy Israel and Philip Seeman and Brian F O'dowd},
  journal={Nature},
  year={1990},
  volume={347},
  pages={80-83}
}
RECEPTORS for dopamine have been classified into two functional types, D1 and D2 (refs 1,2). They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins3. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases4,5. Dopamine D1 and D2 receptors are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia6,7, and may also have a role in… Expand
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
TLDR
The cloning of a gene encoding a 477-amino-acid protein with strong homology to the cloned Dt receptor is reported here the existence of a dopamine D1-like receptor with these characteristics had not been predicted and may represent an alternative pathway for dopamine-mediated events and regulation of D2 receptor activity. Expand
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
TLDR
The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine. Expand
The Dopamine D1D Receptor
TLDR
The isolation of four distinct vertebrate dopamine D1 receptor subtypes suggests the existence of additional mammalian D1 like receptor genes that may account for the observed pharmacological and biochemical multiplicity of dopamine D 1-like receptor mediated events. Expand
Gene and Promoter Structures of the Dopamine Receptors
TLDR
All the evidence suggests that the genes encoding the dopamine receptor subtypes have diverse transcriptional regulation mechanisms that result in cell-specific expression patterns that are coupled with different molecular functions. Expand
Chromosomal localization of three human D5 dopamine receptor genes.
TLDR
Genetic predisposition to imbalances in dopaminergic transmission may underlie several neurological disorders, including schizophrenia, manic depression, Tourette syndrome, Parkinson disease, Huntington disease, and alcohol abuse. Expand
Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus.
TLDR
The localization of the D5 dopamine receptor (DRD5) gene to 4p15.1-p 15.33 suggests the possibility that cis-position effects could be responsible for the altered D1-type dopamine receptor number observed in HD tissues or that the DRD5 gene could be a candidate for some of the abnormalities associated with the Wolf-Hirschhorn syndrome. Expand
Functional coupling of human D2, D3, and D4 dopamine receptors in HEK293 cells.
TLDR
In these cells, activation of D2, D3 or D4 receptors resulted in the inhibition of forskolin-stimulated adenylate cyclase activity in a dose responsive manner, and ribonuclease protection studies demonstrated the presence of D4 dopamine receptor mRNA in human brain regions. Expand
The renal dopamine receptors.
TLDR
Dopamine is an endogenous catecholamine that modulates many functions including behavior, movement, nerve conduction, hormone synthesis and release, blood pressure, and ion fluxes and has been postulated to act as an intrarenal natriuretic hormone. Expand
The Dopamine D1 Receptors
TLDR
Dopaminergic receptors are members of a large gene family of hormone/neurotransmitter receptors that exert their biological actions via signal transduction pathways that involve guanine nucleotide-binding proteins. Expand
G protein-coupled receptor kinases as regulators of dopamine receptor functions.
TLDR
The data demonstrate that the dopamine signaling in defined neuronal types in vivo is regulated by specific and finely orchestrated actions of GRK isoforms. Expand
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References

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Cloning and expression of a rat D2 dopamine receptor cDNA
TLDR
This receptor has been characterized on the basis of three criteria: the deduced amino-acid sequence which reveals that it is a member of the family of G-protein-coupled receptors; the tissue distribution of the mRNA which parallels that of the D2 dopamine receptor; and the pharmacological profile of mouse fibroblast cells transfected with the cDNA. Expand
Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.
TLDR
The D1-D2 link may be mediated by guanine nucleotide-binding protein components influencing behavior, since the link was missing in over half the postmortem striata from patients with schizophrenia and Huntington disease but was present in human control, Alzheimer, and Parkinson striata. Expand
Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications
The present review focuses on the hypothesized D1/D2 dopamine (DA) receptor classification, originally based on the form of receptor coupling to adenylate cyclase activity. The pharmacologicalExpand
Cloning of two additional catecholamine receptors from rat brain
TLDR
An approach based on the polymerase chain reaction (PCR) was used to isolate additional members of the G‐linked receptor family from a rat striatal λgtII cDNA library and suggests that G‐36 encodes a catecholaminergic receptor. Expand
Chromosomal organization of adrenergic receptor genes.
TLDR
The alpha 1- AR gene is mapped to chromosome 5q32----q34, the same position as beta 2-AR, and the beta 1-AR gene to chromosome 10q24----q26, the region where alpha 2- AR is located, as well as the sequence similarity that exists among all the ARs. Expand
Allelic association of human dopamine D2 receptor gene in alcoholism.
TLDR
The polymorphic pattern of this receptor gene suggests that a gene that confers susceptibility to at least one form of alcoholism is located on the q22-q23 region of chromosome 11. Expand
Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases.
  • P. Seeman, N. Bzowej, +6 authors W. Tourtellotte
  • Chemistry, Medicine
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
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TLDR
Compared to the neuroleptic-induced and unimodal elevations in D2 of 31% in Alzheimer's disease and 37% in Huntington's disease, the schizophrenic striata with a mode of 26 pmol/g (105% above control) appear to contain more D2 receptors than can be accounted for by the Neuroleptic administration alone. Expand
The distribution of a dopamine D2 receptor mRNA in rat brain
TLDR
Comparison of the distributions of the mRNA and ligand binding indicates that both presynaptic and postsynaptic D2 receptors of the nigrostriatal, mesolimbic and mesocortical pathways are derived from the same mRNA. Expand
Structure of the adrenergic and related receptors.
TLDR
The isolation and sequencing of a number of G protein-coupled receptors has now provided extensive primary structure information for this family of homologous proteins, suggesting that the family of proteins may grow to include receptors for many neurotransmitters and perhaps many peptide hormones. Expand
Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
TLDR
Results indicate that post-translational modification by palmitate of beta 2AR may play a crucial role in the normal coupling of the receptor to the adenylyl cyclase signal transduction system. Expand
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