Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.

@article{Pandey2011HumanDM,
  title={Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.},
  author={Udai Bhan Pandey and Charles D Nichols},
  journal={Pharmacological reviews},
  year={2011},
  volume={63 2},
  pages={411-36}
}
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic model organism for understanding molecular mechanisms of human diseases. Many basic biological, physiological, and neurological properties are conserved between mammals and D. melanogaster, and nearly 75% of human disease-causing genes are believed to have a functional homolog in the fly. In the discovery process for therapeutics, traditional approaches employ high-throughput screening for small… CONTINUE READING
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