Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.

@article{Gardiol2006HumanDL,
  title={Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.},
  author={Daniela N Gardiol and Alberto Zacchi and Francesca Petrera and Giorgio Stanta and Lawrence Banks},
  journal={International journal of cancer},
  year={2006},
  volume={119 6},
  pages={1285-90}
}
Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell polarity and proliferation control comes from studies on the Drosophila tumor suppressors discs large (Dlg), scribble (Scrib) and lethal giant larvae (lgl). Mammalian homologues of these proteins have been described and are conserved in sequence and function. Human Dlg (hDlg) and Scrib were independently shown to be down-regulated during malignant progression. This, and… CONTINUE READING