Human dendritic cells pulsed with specific lipopeptides stimulate autologous antigen-specific T cells without the addition of exogenous maturation factors.

@article{Jones2008HumanDC,
  title={Human dendritic cells pulsed with specific lipopeptides stimulate autologous antigen-specific T cells without the addition of exogenous maturation factors.},
  author={Kathryn L. Jones and Lorena Elizabeth Brown and Emily M Eriksson and Rosemary A. Ffrench and Philippe Latour and Bruce Edward Loveland and Dominic M. Wall and Stuart K. Roberts and David C Jackson and Eric James Gowans},
  journal={Journal of viral hepatitis},
  year={2008},
  volume={15 10},
  pages={
          761-72
        }
}
SUMMARY Serum-free culture conditions to generate immature human monocyte-derived DC (Mo-DC) were optimized, and the parameters that influence their maturation after exposure to lipopeptides containing CD4(+) and CD8(+) T-cell epitopes were examined. The lipopeptides contained a single CD4(+) helper T-cell epitopes, one of a number of human leucocyte antigen (HLA)-A2-restricted cytotoxic T-cell epitope and the lipid Pam2Cys. To ensure complete maturation of the Mo-DC, we examined (i) the… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Monocytederived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile

  • HC Gelderblom, LEJ Nijhuis, EC de Jong
  • Liver Int
  • 2007

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