Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro.

@article{Manna2002HumanDC,
  title={Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro.},
  author={Partha Pratim Manna and Thalachallour Mohanakumar},
  journal={Journal of leukocyte biology},
  year={2002},
  volume={72 2},
  pages={312-20}
}
Dendritic cells (DC) are an important subset of antigen-presenting cells characterized by their potent capacity to activate immunologically naïve T cells. However, their role in effector function in tumor resistance is less well characterized. We report here that activated human peripheral blood DC acquire a potent antitumor effect against breast cancer cell lines in vitro, leading to growth inhibition and apoptosis of the tumor cell. The antitumor effect of DC was augmented by proinflammatory… CONTINUE READING