Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy.

@article{Sayama2013HumanDM,
  title={Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy.},
  author={Seisuke Sayama and Takeshi Nagamatsu and Danny J. Schust and Naoko Itaoka and Mayuko Ichikawa and Kei Kawana and Takahiro Yamashita and Shiro Kozuma and Tomoyuki Fujii},
  journal={Journal of reproductive immunology},
  year={2013},
  volume={100 2},
  pages={109-17}
}
In human pregnancy, CD14⁺ decidual macrophages (DMs) are the dominant professional antigen-presenting cells in the decidua, comprising 20-30% of the local leukocyte population. Although the relevance of DMs to feto-maternal immune tolerance has been described, the molecular mechanisms underlying these functions have not been fully elucidated. B7-H1, a costimulatory ligand in the B7 family, negatively modulates T cell activity by binding to its corresponding receptor, PD-1. The present study… CONTINUE READING
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