Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization.

@article{Falany2006HumanCS,
  title={Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization.},
  author={Charles N. Falany and Dongning He and No{\'e} Dumas and Andra R. Frost and Josie L. Falany},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2006},
  volume={102 1-5},
  pages={214-21}
}
Sulfation is an important Phase II conjugation reaction involved in the synthesis and metabolism of steroids in humans. Two different isoforms (2B1a and 2B1b) are encoded by the sulfotransferase (SULT) 2B1 gene utilizing different start sites of transcription resulting in the incorporation of different first exons. SULT2B1a and SULT2B1b are 350 and 365 amino acids in length, respectively, and the last 342 aa are identical. Message for both SULT2B1 isoforms is present in human tissues although… CONTINUE READING
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