Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

Abstract

Aldo-ketoreductase 1C (AKR1C) enzymes catalyze the NADPH-dependent reduction of ketosteroids to hydroxysteroids. They are Phase I metabolizing enzymes for natural and synthetic steroid hormones. They convert 5alpha-dihydrotestosterone (Dht, potent androgen) to 3alpha/beta-androstanediols (inactive androgens) and the prodrug tibolone (Tib) to estrogenic… (More)
DOI: 10.1074/jbc.M809465200

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Cite this paper

@article{Jin2009HumanCH, title={Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.}, author={Yi Jin and Ling Duan and Seon Hwa Lee and Helenius J. Kloosterboer and Ian A Blair and Trevor M Penning}, journal={The Journal of biological chemistry}, year={2009}, volume={284 15}, pages={10013-22} }