Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts.

@article{Cerboni2000HumanCS,
  title={Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts.},
  author={Cristina Cerboni and Mehrdad Mousavi-Jazi and A. W. van de Linde and K. -O. S{\"o}derstr{\"o}m and Maria Brytting and Britta E Wahren and Klas K{\"a}rre and Ennio Carbone},
  journal={Journal of immunology},
  year={2000},
  volume={164 9},
  pages={4775-82}
}
NK cells play a key role in the control of CMV infection in mice, but the mechanism by which NK cells can recognize and kill CMV-infected cells is unclear. In this study, the modulation of NK cell susceptibility of human CMV (hCMV)-infected cells was examined. We used a human lung and a human foreskin fibroblast cell line infected with clinical isolates (4636, 13B, or 109B) or with laboratory strains (AD169, Towne). The results indicate that all three hCMV clinical isolates confer a strong NK… CONTINUE READING
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