Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry.

@article{Nogalski2011HumanCP,
  title={Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry.},
  author={Maciej T. Nogalski and Gary C Chan and Emily V. Stevenson and Scarlet Gray and Andrew D Yurochko},
  journal={Journal of virology},
  year={2011},
  volume={85 3},
  pages={
          1360-9
        }
}
We have established that human cytomegalovirus (HCMV) infection modulates the biology of target primary peripheral blood monocytes, allowing HCMV to use monocytes as "vehicles" for its systemic spread. HCMV infection of monocytes results in rapid induction of phosphatidylinositol-3-kinase [PI(3)K] and NF-κB activities. Integrins, which are upstream of the PI(3)K and NF-κB pathways, were shown to be involved in HCMV binding to and entry into fibroblasts, suggesting that receptor ligand-mediated… CONTINUE READING

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