Human cytomegalovirus inhibits tapasin-dependent peptide loading and optimization of the MHC class I peptide cargo for immune evasion.

@article{Park2004HumanCI,
  title={Human cytomegalovirus inhibits tapasin-dependent peptide loading and optimization of the MHC class I peptide cargo for immune evasion.},
  author={Boyoun Park and Youngkyun Kim and Jinwook Shin and Sunray Lee and Kwangmin Cho and Klaus Fr{\"u}h and Sungwook Lee and Kwangseog Ahn},
  journal={Immunity},
  year={2004},
  volume={20 1},
  pages={71-85}
}
The immune evasion protein US3 of human cytomegalovirus binds to and arrests MHC class I molecules in the endoplasmic reticulum (ER). However, substantial amounts of class I molecules still escape US3-mediated ER retention, suggesting that not all class I alleles are affected equally by US3. Here, we identify tapasin inhibition as the mechanism of MHC retention by US3. US3 directly binds tapasin and inhibits tapasin-dependent peptide loading, thereby preventing the optimization of the peptide… CONTINUE READING