Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1.

@article{Bresnahan1996HumanCI,
  title={Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1.},
  author={Wade A. Bresnahan and Istvan Boldogh and Emily A Thompson and Thomas Albrecht},
  journal={Virology},
  year={1996},
  volume={224 1},
  pages={150-60}
}
Human embryonic lung fibroblasts (LU) can be productively infected with human cytomegalovirus (HCMV). During the course of productive infection, the virus elicits a number of responses that resemble certain aspects of G1 cell cycle progression. The virus activates cyclin E/Cdk2 kinase in both subconfluent, serum-arrested, and density-arrested cultures. Activation of cyclin E-dependent kinase is due, in part, to induction of cyclin E and, in part, to inhibition of the cyclin kinase inhibitors… CONTINUE READING

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