Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.

@article{Ahn1996HumanCI,
  title={Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.},
  author={Kwangseog Ahn and Alexandra Angulo and Peter Ghazal and Per A. Peterson and Yaoming Yang and Klaus Fr{\"u}h},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 20},
  pages={10990-5}
}
The human cytomegalovirus (HCMV) genomic unique short (US) region encodes a family of homologous genes essential for the inhibition of major histocompatibility complex (MHC) class I-mediated antigen presentation during viral infection. Here we show that US3, the only immediate early (IE) gene within the US region, encodes an endoplasmic reticulum-resident glycoprotein that prevents intracellular transport of MHC class I molecules. In contrast to the rapid degradation of newly synthesized MHC… CONTINUE READING