Human cytomegalovirus infection increases the number of ouabain-binding sites in human fibroblasts.

@article{Altamirano1994HumanCI,
  title={Human cytomegalovirus infection increases the number of ouabain-binding sites in human fibroblasts.},
  author={An{\'i}bal A Altamirano and Michael P Fons and J. M. Russell and Edward J. Cragoe and Thomas Albrecht},
  journal={Virology},
  year={1994},
  volume={199 1},
  pages={151-9}
}
Infection of permissive human embryo fibroblasts (MRC-5) with human cytomegalovirus (HCMV) increased the number of copies of the Na+,K(+)-ATPase (the Na+ pump) in the plasma membrane, measured as ouabain-binding sites. The increase was preceded by cell enlargement by about 24 hr, becoming significant between 48 and 72 hr after infection. Reduction in Na+ or Cl- concentration in the culture media immediately after infection partially prevented the increase in the number of ouabain-binding sites… CONTINUE READING

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