Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression.


The interferon-inducible Sp100 proteins are thought to play roles in the chromatin pathway and in transcriptional regulation. Sp100A, the smallest isoform, is one of the major components of PML nuclear bodies (NBs) that exhibit intrinsic antiviral activity against several viruses. Since PML NBs are disrupted by the immediate-early 1 (IE1) protein during… (More)
DOI: 10.1128/JVI.00758-11


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