Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.

  title={Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.},
  author={Regine Heilbronn and Inka Albrecht and S Stephan and Alexander B{\"u}rkle and Harald zur Hausen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 23},
JC virus, a human papovavirus, is the causative agent of the demyelinating brain disease progressive multifocal leucoencephalopathy (PML). PML is a rare but fatal disease which develops as a complication of severe immunosuppression. Latent JC virus is harbored by many asymptomatic carriers and is transiently reactivated from the latent state upon immunosuppression. JC virus has a very restricted host range, with human glial cells being the only tissue in which it can replicate at reasonable… CONTINUE READING


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