Human cytomegalovirus induces IL-6 and TNF alpha from macrophages and microglial cells: possible role in neurotoxicity.

@article{Pulliam1995HumanCI,
  title={Human cytomegalovirus induces IL-6 and TNF alpha from macrophages and microglial cells: possible role in neurotoxicity.},
  author={Lynn Pulliam and Deborah A. Moore and David C. West},
  journal={Journal of neurovirology},
  year={1995},
  volume={1 2},
  pages={
          219-27
        }
}
Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregates preferentially infected a microglial/macrophage (M/M) and caused a neuropathology that differed between strains and could occur in the absence of antigen expression. We extended these studies by infecting a human… CONTINUE READING

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