Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways.

@article{Shen2004HumanCC,
  title={Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways.},
  author={Yufeng Shen and Budi Utama and Jingxiong Wang and M Raveendran and Duraisamy Senthil and W. James Waldman and John D Belcher and Gregory Vercellotti and Daniel Mart{\'i}n and B M Mitchelle and Xue Long Wang},
  journal={Circulation research},
  year={2004},
  volume={94 10},
  pages={1310-7}
}
Atherosclerosis is the leading cause of death in the United States, and human cytomegalovirus (HCMV), a member of the herpes virus family, may play a role in the development of the disease. We previously showed that HCMV regulated endothelial apoptosis. In this study, we investigated the induction of apoptosis and signal transduction pathways regulating this process in HCMV-infected endothelial cells. As observed previously, HCMV induced a typical cytopathic effect in human aortic endothelial… CONTINUE READING

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