Human cytomegalovirus binding to fibroblasts is receptor mediated.

  title={Human cytomegalovirus binding to fibroblasts is receptor mediated.},
  author={Hugh P. Taylor and Neil R. Cooper},
  journal={Journal of virology},
  volume={63 9},
The binding of radiolabeled human cytomegalovirus (HCMV) strain AD169 to human lymphocytes, lymphoblastoid cell lines, monocytes, and fibroblasts varied over a 20-fold range. Since maximum binding was observed with human foreskin fibroblasts (HFF), interactions of radiolabeled HCMV with this cell type were analyzed quantitatively. Binding of HCMV to HFF at 4 degrees C was specific and saturable; at low viral inputs specific binding averaged 16.4% of input and nonspecific binding was less than 1… CONTINUE READING