Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains.

@article{Jones1996HumanCU,
  title={Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains.},
  author={Thomas Russel Jones and Emmanuel J H J Wiertz and Lei Sun and Kenneth N. Fish and Jay A. Nelson and Hidde L. Ploegh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 21},
  pages={11327-33}
}
The human cytomegalovirus (HCMV) early glycoprotein products of the US11 and US2 open reading frames cause increased turnover of major histocompatibility complex (MHC) class I heavy chains. Since US2 is homologous to another HCMV gene (US3), we hypothesized that the US3 gene product also may affect MHC class I expression. In cells constitutively expressing the HCMV US3 gene, MHC class I heavy chains formed a stable complex with beta 2-microglobulin. However, maturation of the N-linked glycan of… CONTINUE READING

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