Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus.

@article{Metzger1994HumanCU,
  title={Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus.},
  author={C Metzger and Detlef Michel and Karin Schneider and Anke L{\"u}ske and H. J. Schlicht and Thomas Mertens},
  journal={Journal of virology},
  year={1994},
  volume={68 12},
  pages={8423-7}
}
We analyzed whether the phosphotransferase encoded by the UL97 open reading frame of human cytomegalovirus (HCMV) alone is sufficient to confer ganciclovir (GCV) susceptibility to a foreign virus. Two vaccinia virus recombinants (T1 and A5) containing the UL97 open reading frames from a GCV-sensitive HCMV and from a GCV-resistant strain were constructed. T1 exhibited a GCV-sensitive phenotype in plaque reduction assays, whereas A5 did not. Moreover, T1-infected cell cultures showed a strongly… CONTINUE READING

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