Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells.

@article{Browne2003HumanCU,
  title={Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells.},
  author={Edward P. Browne and Thomas E. Shenk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 20},
  pages={11439-44}
}
The initial interaction of human cytomegalovirus with fibroblasts triggers, and then partially blocks, an innate immune response pathway that leads to the induction of IFN-responsive genes and proinflammatory chemokines. Infection of fibroblasts with human cytomegalovirus inhibited their ability to respond to exogenous IFN. Consistent with the observation that the block did not depend on de novo viral protein synthesis, ectopic expression of the viral UL83-coded pp65, an abundant virion protein… CONTINUE READING

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