Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors.

@article{Mingari2005HumanCT,
  title={Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors.},
  author={Maria Cristina Mingari and Gabriella Pietra and Alessandro Moretta},
  journal={Current opinion in immunology},
  year={2005},
  volume={17 3},
  pages={312-9}
}
MHC class-1-specific inhibitory receptors were originally described in NK cells, in which they represent an important fail-safe mechanism that induces NK cell tolerance to normal self cells. These inhibitory NK receptors (iNKRs) were subsequently found expressed on different T cell subsets, primarily CD8(+) cytolytic T lymphocytes (CTLs), in which they can inhibit T cell receptor mediated functions. Some iNKR(+) CTLs are HLA-E-restricted, represent oligo- or monoclonal expansions, and can play… CONTINUE READING

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