Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.

@article{Chatterjee2003HumanCP,
  title={Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.},
  author={Parnali Chatterjee and M. Franklin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 11},
  pages={
          1391-7
        }
}
The concurrent use of herbal medicinals with prescription and over-the-counter drugs carries a risk for unanticipated adverse drug-botanical pharmacokinetic interactions, particularly as a result of cytochrome P450 (P450) inhibition. Extracts of goldenseal (Hydrastis canadensis) containing approximately equal concentrations ( approximately 17 mM) of two methylenedioxyphenyl alkaloids, berberine and hydrastine, inhibited with increasing potency (CYP2C9) diclofenac 4'-hydroxylation, (CYP2D6… Expand
Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes.
Effects of herbal products and their constituents on human cytochrome P450(2E1) activity.
Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail
Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions
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