Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.

@article{Chatterjee2003HumanCP,
  title={Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.},
  author={Parnali Chatterjee and Michael R. Franklin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 11},
  pages={
          1391-7
        }
}
  • P. Chatterjee, M. Franklin
  • Published 1 November 2003
  • Biology, Chemistry
  • Drug metabolism and disposition: the biological fate of chemicals
The concurrent use of herbal medicinals with prescription and over-the-counter drugs carries a risk for unanticipated adverse drug-botanical pharmacokinetic interactions, particularly as a result of cytochrome P450 (P450) inhibition. Extracts of goldenseal (Hydrastis canadensis) containing approximately equal concentrations ( approximately 17 mM) of two methylenedioxyphenyl alkaloids, berberine and hydrastine, inhibited with increasing potency (CYP2C9) diclofenac 4'-hydroxylation, (CYP2D6… 

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