Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.

@article{Chatterjee2003HumanCP,
  title={Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.},
  author={P. Chatterjee and M. Franklin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 11},
  pages={
          1391-7
        }
}
  • P. Chatterjee, M. Franklin
  • Published 2003
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
The concurrent use of herbal medicinals with prescription and over-the-counter drugs carries a risk for unanticipated adverse drug-botanical pharmacokinetic interactions, particularly as a result of cytochrome P450 (P450) inhibition. Extracts of goldenseal (Hydrastis canadensis) containing approximately equal concentrations ( approximately 17 mM) of two methylenedioxyphenyl alkaloids, berberine and hydrastine, inhibited with increasing potency (CYP2C9) diclofenac 4'-hydroxylation, (CYP2D6… Expand
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Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects
TLDR
Time-dependent inhibition experiments were conducted to evaluate the ability of berberine and hydrastinine to inhibit major P450 activities in human liver microsomes by using a cocktail of isozyme-specific substrate probes to inform the development of a physiologically based pharmacokinetic model that can be used to predict potential clinically relevant goldenseal-drug interactions. Expand
Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites.
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It is demonstrated that berberine preferentially inhibits the estradiol 4-hydroxylation activity of CYP1B1 variants, suggesting that 4-Hydroxyestradiol-mediated toxicity might be reduced by berberines, especially in tissues/tumors highly expressing CYP 1B1. Expand
Screening for inhibitory effect on nine CYP isoforms by 20 herbal medications
We evaluated the potential of 20 herbal medications (HMs), commonly used in Korea, to inhibit the catalytic activities of several cytochrome P450 (CYP) isoforms. The abilities of 500 μg/ml of aqueous… Expand
Corydaline Inhibits Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
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In vitro results suggest that corydaline should be evaluated for potential pharmacokinetic drug interactions in vivo due to potent inhibition of CYP2C19 and CYP3A-mediated midazolam hydroxylation. Expand
Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.
TLDR
It is demonstrated that berberine causes a selective CYP1B1-inhibition, in which Asn228 appears to be crucial, which is a crucial role in the detoxification and bioactivation of polycyclic aromatic hydrocarbons. Expand
Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes.
TLDR
It is concluded that the hydroxylation of compound A is mainly catalyzed by CYP2C8, and thus the reaction can possibly serve as an alternative marker assay for CYP 2C8 in human liver microsomes. Expand
Effects of herbal products and their constituents on human cytochrome P450(2E1) activity.
Ethanolic extracts from fresh Echinacea purpurea and Spilanthes acmella and dried Hydrastis canadensis were examined with regard to their ability to inhibit cytochrome P450(2E1) mediated oxidation of… Expand
Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro.
TLDR
It is suggested that liver CYP enzyme activities are not markedly affected by artepillin C at the recommended daily intake of EEP-B55. Expand
Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail
TLDR
The present work has shown that the N-in-one cocktail is a rapid and reliable method that can be used as an initial screen to help prioritize products that require more detailed investigations and it can also be applied to monitor product variability. Expand
Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions
TLDR
For the purpose of better understanding the interactions of natural products with CYP2C9, a comprehensively reviewed the characteristics of CYP1C8, the natural ingredients that inhibit CYP9, the related research approaches and strategies, the types of inhibition and the underlying mechanisms. Expand
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