Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.

@article{Chatterjee2003HumanCP,
  title={Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.},
  author={P. Chatterjee and M. Franklin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 11},
  pages={
          1391-7
        }
}
  • P. Chatterjee, M. Franklin
  • Published 2003
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
The concurrent use of herbal medicinals with prescription and over-the-counter drugs carries a risk for unanticipated adverse drug-botanical pharmacokinetic interactions, particularly as a result of cytochrome P450 (P450) inhibition. Extracts of goldenseal (Hydrastis canadensis) containing approximately equal concentrations ( approximately 17 mM) of two methylenedioxyphenyl alkaloids, berberine and hydrastine, inhibited with increasing potency (CYP2C9) diclofenac 4'-hydroxylation, (CYP2D6… Expand
Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects
TLDR
Time-dependent inhibition experiments were conducted to evaluate the ability of berberine and hydrastinine to inhibit major P450 activities in human liver microsomes by using a cocktail of isozyme-specific substrate probes to inform the development of a physiologically based pharmacokinetic model that can be used to predict potential clinically relevant goldenseal-drug interactions. Expand
Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites.
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Screening for inhibitory effect on nine CYP isoforms by 20 herbal medications
We evaluated the potential of 20 herbal medications (HMs), commonly used in Korea, to inhibit the catalytic activities of several cytochrome P450 (CYP) isoforms. The abilities of 500 μg/ml of aqueousExpand
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In vitro results suggest that corydaline should be evaluated for potential pharmacokinetic drug interactions in vivo due to potent inhibition of CYP2C19 and CYP3A-mediated midazolam hydroxylation. Expand
Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling.
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It is demonstrated that berberine causes a selective CYP1B1-inhibition, in which Asn228 appears to be crucial, which is a crucial role in the detoxification and bioactivation of polycyclic aromatic hydrocarbons. Expand
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It is concluded that the hydroxylation of compound A is mainly catalyzed by CYP2C8, and thus the reaction can possibly serve as an alternative marker assay for CYP 2C8 in human liver microsomes. Expand
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Ethanolic extracts from fresh Echinacea purpurea and Spilanthes acmella and dried Hydrastis canadensis were examined with regard to their ability to inhibit cytochrome P450(2E1) mediated oxidation ofExpand
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It is suggested that liver CYP enzyme activities are not markedly affected by artepillin C at the recommended daily intake of EEP-B55. Expand
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TLDR
The present work has shown that the N-in-one cocktail is a rapid and reliable method that can be used as an initial screen to help prioritize products that require more detailed investigations and it can also be applied to monitor product variability. Expand
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