Human cytochrome P450 mono-oxygenase system is suppressed by propofol.

  title={Human cytochrome P450 mono-oxygenase system is suppressed by propofol.},
  author={T L Chen and Tzuu-Huei Ueng and S. H. Chen and Phil Ho Lee and Shou Zen Fan and Chang Chin Liu},
  journal={British journal of anaesthesia},
  volume={74 5},
We have studied the effect of propofol on the cytochrome P450-dependent mono-oxygenase system in human liver microsomes by assaying mono-oxygenase activities toward specific cytochrome P450 isoform test substrates, aniline, 7-ethoxycoumarin, benzphetamine and benzo(a) pyrene. Propofol inhibited benzo(a)pyrene hydroxylation to a greater extent than the oxidative metabolism of the other test substrates, even at 0.05 mmol litre-1. The degrees of inhibition of benzphetamine N-demethylation and 7… CONTINUE READING