Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene.

@article{Birkett1996HumanCP,
  title={Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene.},
  author={Donald Birkett and John W. Edwards and M. E. Veronese and Wichittra Tassaneeyakul and Robert H. Tukey and John O. Miners},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={276 1},
  pages={101-8}
}
The conversion of toluene and o-, m- and p-xylene to their respective side-chain and ring monohydroxylated metabolites by human liver microsomes was investigated. Methyl hydroxylation, to form a benzylalcohol, was the major metabolic pathway for all four methylbenzenes. With the exception of 2,4-dimethylphenol formation from m-xylene, ring hydroxylation accounted for < 5% of total metabolite formation. However, regioselectivity of ring hydroxylation was apparent, with hydroxylation occurring… CONTINUE READING

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