Human cytochrome P450 4F3: structure, functions, and prospects

  title={Human cytochrome P450 4F3: structure, functions, and prospects},
  author={L. Corcos and D. Lucas and C. Le Jossic-Corcos and Y. Dr{\'e}ano and B. Sim{\'o}n and Emmanuelle Pl{\'e}e-Gautier and Y. Amet and J. Sala{\"u}n},
  booktitle={Drug metabolism and drug interactions},
  • L. Corcos, D. Lucas, +5 authors J. Salaün
  • Published in
    Drug metabolism and drug…
  • Medicine
  • Abstract Cytochrome P450 4F3 (CYP4F3), originally identified as one of the leukotriene B4 ω-hydroxylases, belongs to a CYP gene family that comprises several members, which participate in the metabolism of various endobiotics, as well as some xenobiotics. The CYP4F gene family is clustered in a 0.5-Mb stretch of genomic DNA on the p13 region of chromosome 19. Apart from the ω-hydroxylation of leukotriene B4 and prostaglandins, CYP4F3 is the main catalyst in the oxidation of fatty acid epoxides… CONTINUE READING
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