Human cytochrome P450 4F3: structure, functions, and prospects

@inproceedings{Corcos2012HumanCP,
  title={Human cytochrome P450 4F3: structure, functions, and prospects},
  author={L. Corcos and D. Lucas and C. Le Jossic-Corcos and Y. Dr{\'e}ano and B. Sim{\'o}n and Emmanuelle Pl{\'e}e-Gautier and Y. Amet and J. Sala{\"u}n},
  booktitle={Drug metabolism and drug interactions},
  year={2012}
}
  • L. Corcos, D. Lucas, +5 authors J. Salaün
  • Published in
    Drug metabolism and drug…
    2012
  • Medicine
  • Abstract Cytochrome P450 4F3 (CYP4F3), originally identified as one of the leukotriene B4 ω-hydroxylases, belongs to a CYP gene family that comprises several members, which participate in the metabolism of various endobiotics, as well as some xenobiotics. The CYP4F gene family is clustered in a 0.5-Mb stretch of genomic DNA on the p13 region of chromosome 19. Apart from the ω-hydroxylation of leukotriene B4 and prostaglandins, CYP4F3 is the main catalyst in the oxidation of fatty acid epoxides… CONTINUE READING
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    References

    SHOWING 1-10 OF 55 REFERENCES
    Expression of the CYP4F3 Gene
    • 66
    • PDF
    Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.
    • 70
    • PDF
    Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles.
    • 49
    cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine.
    • 58
    cDna cloning and expression of CYP4F12, a novel human cytochrome P450.
    • 65
    Myeloid Expression of Cytochrome P450 4F3 Is Determined by a Lineage-specific Alternative Promoter*
    • 26
    • PDF
    Alternative splicing determines the function of CYP4F3 by switching substrate specificity.
    • 125
    • Highly Influential
    Phylogenetic and functional analyses of the cytochrome P450 family 4.
    • 29
    Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine
    • 45
    • PDF