Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.

@article{Bansal2013HumanCP,
  title={Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.},
  author={Seema Bansal and Hindupur K. Anandatheerthavarada and Govindaswamy K Prabu and Ginger L Milne and M Virginia Mart{\'i}n and F Peter Guengerich and Narayan G Avadhani},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 18},
  pages={
          12627-44
        }
}
Human polymorphisms in the 5'-upstream regulatory regions and also protein coding regions of cytochrome P450 2E1 (CYP2E1) are known to be associated with several diseases, including cancer and alcohol liver toxicity. In this study, we report novel mutations in the N-terminal protein targeting regions of CYP2E1 that markedly affect subcellular localization of the protein. Variant W23R/W30R protein (termed W23/30R) is preferentially targeted to mitochondria but very poorly to the endoplasmic… CONTINUE READING
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