Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.

  title={Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.},
  author={R W Wang and D J Newton and N Liu and William M Atkins and A Y Lu},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={28 3},
  • R W Wang, D J Newton, +2 authors A Y Lu
  • Published 2000 in
    Drug metabolism and disposition: the biological…
Testosterone, terfenadine, midazolam, and nifedipine, four commonly used substrates for human cytochrome P-450 3A4 (CYP3A4), were studied in pairs in human liver microsomes and in microsomes from cells containing recombinant human CYP3A4 and P-450 reductase, to investigate in vitro substrate-substrate interaction with CYP3A4. The interaction patterns between compounds with CYP3A4 were found to be substrate-dependent. Mutual inhibition, partial inhibition, and activation were observed in the… CONTINUE READING
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Human cytochrome P 450 3 A 4 - catalyzed testosterone 6 b - hydroxylation and erythromycin N - demethylation : Competition during catalysis

  • RW Wang, DJ Newton, TD Scheri, Lu AYH
  • Drug Metab Dispos
  • 1997
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