Human coronaviruses 229E and NL63: close yet still so far.

  title={Human coronaviruses 229E and NL63: close yet still so far.},
  author={Ronald Dijkman and Lia van der Hoek},
  journal={Journal of the Formosan Medical Association = Taiwan yi zhi},
  volume={108 4},
HCoV-NL63 and HCoV-229E are two of the four human coronaviruses that circulate worldwide. These two viruses are unique in their relationship towards each other. Phylogenetically, the viruses are more closely related to each other than to any other human coronavirus, yet they only share 65% sequence identity. Moreover, the viruses use different receptors to enter their target cell. HCoV-NL63 is associated with croup in children, whereas all signs suggest that the virus probably causes the common… CONTINUE READING

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