Human coronavirus 229E: receptor binding domain and neutralization by soluble receptor at 37 degrees C.

@article{Breslin2003HumanC2,
  title={Human coronavirus 229E: receptor binding domain and neutralization by soluble receptor at 37 degrees C.},
  author={Jamie J. Breslin and Irene M\ork and M. Kathleen Smith and Lotte Katrine Vogel and Erin M. Hemmila and Aurelio Bonavia and Pierre Talbot and Hans Sj{\"o}str{\"o}m and Ove B Nor{\'e}n and Kathryn V. Holmes},
  journal={Journal of virology},
  year={2003},
  volume={77 7},
  pages={4435-8}
}
Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37 degrees C, but not 4 degrees C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37 degrees C that facilitate virus entry. 
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