Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.

@article{Akama2001HumanCG,
  title={Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.},
  author={Tomoya O. Akama and Jun-Ichi Nakayama and Keigo Nishida and Nobuyoshi Hiraoka and Motoshi Suzuki and Jon McAuliffe and Ole Hindsgaul and Michiko N. Fukuda},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 19},
  pages={
          16271-8
        }
}
Human corneal N-acetylglucosamine 6-O-sulfotransferase (hCGn6ST) has been identified by the positional candidate approach as the gene responsible for macular corneal dystrophy (MCD). Because of its high homology to carbohydrate sulfotransferases and the presence of mutations of this gene in MCD patients who lack sulfated keratan sulfate in the cornea and serum, hCGn6ST protein is thought to be a sulfotransferase that catalyzes sulfation of GlcNAc in keratan sulfate. In this report, we analyzed… CONTINUE READING
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