Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens.

@article{Mackroth2011HumanCB,
  title={Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens.},
  author={Maria S. Mackroth and Indu J Malhotra and Peter L. Mungai and Davy Koech and Eric M. Muchiri and Christopher L King},
  journal={Journal of immunology},
  year={2011},
  volume={186 5},
  pages={2780-91}
}
In malaria endemic regions, a fetus is often exposed in utero to Plasmodium falciparum blood-stage Ags. In some newborns, this can result in the induction of immune suppression. We have previously shown these modulated immune responses to persist postnatally, with a subsequent increase in a child's susceptibility to infection. To test the hypothesis that this immune suppression is partially mediated by malaria-specific regulatory T cells (T(regs)) in utero, cord blood mononuclear cells (CBMC… CONTINUE READING