Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion.

@article{Fujino2007HumanCB,
  title={Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion.},
  author={Hisanori Fujino and Hidefumi Hiramatsu and Atsunori Tsuchiya and Akira Niwa and Haruyoshi Noma and Mitsutaka Shiota and Katsutsugu Umeda and Momoko Yoshimoto and Mamoru Ito and Toshio Heike and Tatsutoshi Nakahata},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 13},
  pages={3499-510}
}
Several studies have shown that hepatocytes can be generated from hematopoietic stem cells, but this event is believed to be rare and to require hepatic damage. To investigate this phenomenon in human cells, we used a NOD/SCID/gamma(c)null (NOG) mouse model that can achieve a tremendously high level of chimerism when transplanted with human hematopoietic… CONTINUE READING