Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

@article{Ross2010HumanCA,
  title={Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.},
  author={Jillian L. Ross and Simon M. Plummer and Anja Rode and Nancy L. Scheer and Conrad C Bower and Ortwin Vogel and Colin James Henderson and C. R. Wolf and Clifford R. Elcombe},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={116 2},
  pages={
          452-66
        }
}
Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel "humanized" and knockout models for both receptors were developed to investigate potential… CONTINUE READING
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