Human connexin26 and connexin30 form functional heteromeric and heterotypic channels.

@article{Yum2007HumanCA,
  title={Human connexin26 and connexin30 form functional heteromeric and heterotypic channels.},
  author={Sabrina W. Yum and Junxian Zhang and Virginijus Valiunas and Giedrius Kanaporis and Peter R. Brink and Thomas W. White and Steven S. Scherer},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={293 3},
  pages={C1032-48}
}
Mutations in GJB2 and GJB6, the genes that encode the human gap junction proteins connexin26 (Cx26) and connexin30 (Cx30), respectively, cause hearing loss. Cx26 and Cx30 are both expressed in the cochlea, leading to the potential formation of heteromeric hemichannels and heterotypic gap junction channels. To investigate their interactions, we expressed human Cx26 and Cx30 individually or together in HeLa cells. When they were expressed together, Cx26 and Cx30 appeared to interact directly (by… CONTINUE READING
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