Human conditions of insulin-like growth factor-I (IGF-I) deficiency

  title={Human conditions of insulin-like growth factor-I (IGF-I) deficiency},
  author={Juan Enrique Puche and Inma Castilla-Cortazar},
  booktitle={Journal of Translational Medicine},
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). IGF-I is a closely regulated hormone. Consequently, its logical therapeutical applications seems to be… CONTINUE READING


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