Human commensals producing a novel antibiotic impair pathogen colonization

  title={Human commensals producing a novel antibiotic impair pathogen colonization},
  author={Alexander Zipperer and Martin C. Konnerth and Claudia Laux and Anne Berscheid and D. Janek and C. Weidenmaier and M. Burian and Nadine A. Schilling and Christoph J. Slavetinsky and M. Marschal and M. Willmann and H. Kalbacher and B. Schittek and H. Br{\"o}tz-Oesterhelt and Stephanie Grond and A. Peschel and B. Krismer},
  • Alexander Zipperer, Martin C. Konnerth, +14 authors B. Krismer
  • Published 2016
  • Biology, Medicine
  • Nature
  • The vast majority of systemic bacterial infections are caused by facultative, often antibiotic-resistant, pathogens colonizing human body surfaces. [...] Key Result Lugdunin is bactericidal against major pathogens, effective in animal models, and not prone to causing development of resistance in S. aureus. Notably, human nasal colonization by S. lugdunensis was associated with a significantly reduced S. aureus carriage rate, suggesting that lugdunin or lugdunin-producing commensal bacteria could be valuable for…Expand Abstract
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