Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool.

@article{Falguires2008HumanCT,
  title={Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool.},
  author={Thomas Falgui{\`e}res and Matthias Maak and Claus von Weyhern and Marianne Sarr and Xavier Sastre and M Poupon and Sylvie Robine and Ludger Johannes and Klaus-Peter Janssen},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 8},
  pages={2498-508}
}
The targeting of solid tumors requires delivery tools that resist intracellular and extracellular inactivation, and that are taken up specifically by tumor cells. We have shown previously that the recombinant nontoxic B-subunit of Shiga toxin (STxB) can serve as a delivery tool to target digestive tumors in animal models. The aim of this study was to expand these experiments to human colorectal cancer. Tissue samples of normal colon, benign adenomas, colorectal carcinomas, and liver metastases… CONTINUE READING
27 Citations
45 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Similar Papers

Loading similar papers…