Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape.

@article{Huber2005HumanCC,
  title={Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape.},
  author={Veronica Huber and Stefano Fais and Manuela Iero and Luana Lugini and Paola Canese and Paola Squarcina and Annamaria Zaccheddu and Marisa Colone and Giuseppe Arancia and Massimo Gentile and Ettore Seregni and Roberta Valenti and Giuseppina Ballabio and Filiberto Belli and Ermanno Leo and Giorgio Parmiani and Licia Rivoltini},
  journal={Gastroenterology},
  year={2005},
  volume={128 7},
  pages={1796-804}
}
BACKGROUND & AIMS Normal and neoplastic cells release microvesicles, whose effects on the immune system still need to be elucidated. Because human colorectal cancer cells are hypothesized to escape immune recognition by expressing proapoptotic molecules, we investigated whether microvesicles bearing Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand and inducing apoptosis of activated T cells are secreted by colorectal cancer cells both in vitro and in affected patients… CONTINUE READING