Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

@inproceedings{Sarver2009HumanCC,
  title={Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states},
  author={Aaron L. Sarver and Amy J. French and Pedro Miguel Martinho Borralho and Venugopal Thayanithy and Ann L. Oberg and Kevin A. T. Silverstein and Bruce W. Morlan and Shaun M. Riska and Lisa A Boardman and Julie M Cunningham and Subbaya Subramanian and Liang Wang and Tom C. Smyrk and Cec{\'i}lia M. P. Rodrigues and Stephen N. Thibodeau and Clifford John Steer},
  booktitle={BMC Cancer},
  year={2009}
}
BackgroundColon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate gene expression. Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression.MethodsTo identify miRNAs that are differentially expressed in tumors and tumor subtypes, we carried out highly sensitive expression… CONTINUE READING
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