Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia.

@article{Malison2006HumanCP,
  title={Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia.},
  author={Robert Malison and Henry R. Kranzler and Bao-zhu Yang and Joel Gelernter},
  journal={Psychiatric genetics},
  year={2006},
  volume={16 6},
  pages={245-9}
}
Considerable research points to the importance of genetic mechanisms in psychostimulant addiction. Behavioral sensitization, a well-documented response to repeated stimulant exposure, may be mechanistically important in clinical features of the disorder, including escalating patterns of drug use, craving and drug-induced paranoia. Basic studies in both Drosophila melanogaster and mice have suggested the importance of circadian rhythm genes in locomotor sensitization and reward. The primary… CONTINUE READING

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