Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.


Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subunit by separase triggers chromosome segregation in anaphase. Vertebrate separase is held inactive by mutually exclusive binding to securin or Cdk1-cyclin B1 and becomes unleashed only upon ubiquitin-dependent degradation of these regulators. Although most separase is… (More)
DOI: 10.1016/j.molcel.2015.03.025


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