Human chromosome 8 (p12-->q22) complements radiosensitivity in the severe combined immune deficiency (SCID) mouse.

@article{Itoh1993HumanC8,
  title={Human chromosome 8 (p12-->q22) complements radiosensitivity in the severe combined immune deficiency (SCID) mouse.},
  author={Masahiro Itoh and Kiyohiro Hamatani and Kenshi Komatsu and Ryoko Araki and Kanako Takayama and Masumi Abe},
  journal={Radiation research},
  year={1993},
  volume={134 3},
  pages={364-8}
}
The severe combined immune deficiency (SCID) mouse shows two kinds of phenotypic abnormalities, a high radiosensitivity and an abnormal immunoglobulin gene recombination. A genetic study has revealed that a mutation exists in chromosome 16. However, several attempts to isolate the gene responsible for these phenotypes have been unsuccessful. By making use of the characteristics of radiosensitivity, we conducted complementation experiments to identify a human chromosome which contains the… CONTINUE READING