Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis


Chromokinesins are microtubule plus end-directed motor proteins that bind to chromosome arms. In Xenopus egg cell-free extracts, Xkid and Xklp1 are essential for bipolar spindle formation but the functions of the human homologues, hKID (KIF22) and KIF4A, are poorly understood. By using RNAi-mediated protein knockdown in human cells, we find that only co… (More)
DOI: 10.1083/jcb.201110060


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