Human chorionic gonadotropin induces interleukin-1 gene expression in rat Leydig cells in vivo.

@article{Lin1993HumanCG,
  title={Human chorionic gonadotropin induces interleukin-1 gene expression in rat Leydig cells in vivo.},
  author={T F Lin and Dongmei Wang and Madan L. Nagpal},
  journal={Molecular and cellular endocrinology},
  year={1993},
  volume={95 1-2},
  pages={
          139-45
        }
}
Luteinizing hormone (LH)/human chorionic gonadotropin (hCG) causes inflammatory-type responses in the testis. In the present study, we evaluated the effects of hCG on Leydig cell interleukin-1 (IL-1) gene expression. Using monoclonal antibody (ED2) staining for macrophages, our Leydig cell preparations had no significant contamination with macrophages. When purified Leydig cells from normal rats were cultured for 24 h and then treated with IL-1 beta (1-100 ng/ml) for 6 h, IL-1 beta induced dose… CONTINUE READING

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