Human chorionic gonadotrophin attenuates NF-kappaB activation and cytokine expression of endometriotic stromal cells.

@article{Huber2007HumanCG,
  title={Human chorionic gonadotrophin attenuates NF-kappaB activation and cytokine expression of endometriotic stromal cells.},
  author={Ambros V. Huber and Leila Saleh and Johanna Prast and Peter Haslinger and Martin Kn{\"o}fler},
  journal={Molecular human reproduction},
  year={2007},
  volume={13 8},
  pages={595-604}
}
Recently, a clinical study provided evidence that treatment of endometriotic women with human chorionic gonadotrophin (hCG) alleviates disease-related pain and sleeplessness suggesting therapeutic effects of the hormone. Since endometriosis is associated with aberrant concentrations of inflammatory mediators in the peritoneal fluid, we investigated whether hCG may affect cytokine-dependent activation of the key-regulatory transcription factor NF-kappaB and expression of two nuclear factor kappa… CONTINUE READING

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