Human chondrocyte viability after treatment with local anesthetic and/or magnesium: results from an in vitro study.

@article{Baker2011HumanCV,
  title={Human chondrocyte viability after treatment with local anesthetic and/or magnesium: results from an in vitro study.},
  author={J. Baker and D. Byrne and P. Walsh and K. Mulhall},
  journal={Arthroscopy : the journal of arthroscopic \& related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association},
  year={2011},
  volume={27 2},
  pages={
          213-7
        }
}
  • J. Baker, D. Byrne, +1 author K. Mulhall
  • Published 2011
  • Medicine
  • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
PURPOSE We aimed to assess the effect on chondrocyte viability of adding magnesium to a variety of commonly available local anesthetic agents. METHODS Human chondrocytes were grown under standard culture conditions. Cells were exposed to a local anesthetic agent with the addition of magnesium (10%, 20%, or 50%). Cells were also exposed to the varying concentrations of magnesium and 0.9% saline solution. Untreated cells served as controls. The CellTiter 96 AQueous One Solution Cell… Expand
In vitro assessment of human chondrocyte viability after treatment with local anaesthetic, magnesium sulphate or normal saline
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A dose-dependent reduction in chondrocyte viability after treatment with common local anaesthetic agents was confirmed, and Magnesium sulphate is a potential alternative intra-articular analgesic agent. Expand
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TLDR
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TLDR
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  • K. Beitzel, M. Mccarthy, +7 authors A. Mazzocca
  • Medicine
  • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2013
TLDR
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Toxicity of Five Local Anesthesia Drugs on Cells and Multipotent Stem Cells
TLDR
The studies have indicated that MSCs is more sensitive to local anesthetics in comparison with chondrocytes, and it is recommended to use drugs which are safer (such as ropivacaine) in procedures including stem cell therapy, prolonged anesthesia and tissues are repairing. Expand
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