Human cholesterol synthesis measurement using deuterated water. Theoretical and procedural considerations.

@article{Jones1993HumanCS,
  title={Human cholesterol synthesis measurement using deuterated water. Theoretical and procedural considerations.},
  author={Peter Jh Jones and Caroline Leitch and Z. C. Li and William E. Connor},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1993},
  volume={13 2},
  pages={247-53}
}
Human cholesterogenesis is measurable as the rate of incorporation of deuterium derived from deuterium oxide (D2O) within the body water pool into plasma or erythrocyte cholesterol pools. Oral D2O equilibrates across body water, thus enabling extracellular sampling of pools (such as urine) to serve as accurate indicators of intracellular deuterium enrichments at the point of synthesis. Required doses of D2O fall below the threshold associated with negative side effects. Deuterium/carbon… CONTINUE READING

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