Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy

@article{Kiviskk2006HumanCF,
  title={Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy},
  author={Pia Kivis{\"a}kk and Barbara H. Tucky and T. Wei and James J Campbell and Richard M Ransohoff},
  journal={BMC Immunology},
  year={2006},
  volume={7},
  pages={14 - 14}
}
Circulating memory T cells can be divided into tissue-specific subsets, which traffic through distinct tissue compartments during physiologic immune surveillance, based on their expression of adhesion molecules and chemokine receptors. We reasoned that a bias (either enrichment or depletion) of CSF T cell expression of known organ-specific trafficking determinants might suggest that homing of T cells to the subarachnoid space could be governed by a CNS-specific adhesion molecule or chemokine… CONTINUE READING

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Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin.

Proceedings of the National Academy of Sciences of the United States of America • 2003
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